Tissue plasminogen activator modulates the cellular and behavioral response to cocaine

  • Rajani Maiyaa, Yan Zhoub, Erin H. Norrisa, Mary Jeanne
  • Published 2009


Cocaine exposure induces long-lasting molecular and structural adaptations in the brain. In this study, we show that tissue plasminogen activator (tPA), an extracellular protease involved in neuronal plasticity, modulates the biochemical and behavioral response to cocaine. When injected in the acute binge paradigm, cocaine enhanced tPA activity in the… (More)


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