Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation.

@article{Centonze2002TissuePA,
  title={Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation.},
  author={Diego Centonze and Emilia Saulle and Antonio Pisani and Paola Bonsi and Domenicantonio Tropepi and Giorgio Bernardi and Paolo Calabresi},
  journal={Neuroreport},
  year={2002},
  volume={13 1},
  pages={115-8}
}
Recent experimental observations indicate that tPA plays a key role in the development of neuronal damage that follows cerebral ischemia and excitotoxicity. In an attempt to clarify how tPA favors ischemia-induced neuronal damage, we performed in vitro electrophysiological experiments in striatal slices by using mice selectively lacking this serine protease.We found that tPA ablation did not affect the membrane depolarization of striatal neurons exposed to combined oxygen and glucose… CONTINUE READING