Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory.

@article{Calabresi2000TissuePA,
  title={Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory.},
  author={Paolo Calabresi and Maddalena Napolitano and Diego Centonze and Girolama Alessandra Marfia and Paolo Gubellini and M A Teule and Nicola Berretta and Giorgio Bernardi and Luigi Frati and Martin Tolu and Alberto Gulino},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 3},
  pages={1002-12}
}
Induction of long-term depression (LTD) in rat striatal slices revealed that this form of synaptic plasticity is coupled to an increased expression of tissue-plasminogen activator (t-PA) mRNA, as detected by the mRNA differential display technique. To further investigate the involvement of this gene in synaptic remodelling following striatal LTD, we recorded electrical activity from mice lacking the gene encoding t-PA (t-PA-KO) and from wild-type (WT) mice. Tetanic stimulation induced LTD in… CONTINUE READING

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