Tissue plasminogen activator concentration dependence of 120 kHz ultrasound-enhanced thrombolysis.

@article{Shaw2008TissuePA,
  title={Tissue plasminogen activator concentration dependence of 120 kHz ultrasound-enhanced thrombolysis.},
  author={George J. Shaw and Jason M. Meunier and Christopher J Lindsell and Christy K. Holland},
  journal={Ultrasound in medicine & biology},
  year={2008},
  volume={34 11},
  pages={
          1783-92
        }
}
It has been known for some time that the application of ultrasound can enhance the efficacy of thrombolytic medications such as recombinant tissue plasminogen activator (rt-PA). Potential clinical applications of this ultrasound-enhanced thrombolysis (UET) include the treatment of myocardial infarction, acute ischemic stroke, deep venous thrombosis and other thrombotic disorders. It may be possible to reduce the dose of rt-PA while maintaining lytic efficacy; however there is little data on the… CONTINUE READING
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