Tissue plasminogen activator and plasminogen activator inhibitor-1 gene polymorphisms in patients with chronic periodontitis.

@article{Grkan2007TissuePA,
  title={Tissue plasminogen activator and plasminogen activator inhibitor-1 gene polymorphisms in patients with chronic periodontitis.},
  author={Ali G{\"u}rkan and G{\"u}lnur Emingil and Buket Han Saygan and Serhat Cinarcik and G Ekin Atilla and Timur K{\"o}se and Afig Huseyinov Berdeli},
  journal={Journal of periodontology},
  year={2007},
  volume={78 7},
  pages={1256-63}
}
BACKGROUND Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) are involved in the pathogenesis of periodontitis by controlling proteolytic events in the extracellular matrix. This study was designed to investigate the association of t-PA and PAI-1 gene polymorphisms with chronic periodontitis (CP). METHODS One hundred eighty-nine subjects were included. Genomic DNA was obtained from the peripheral blood of 84 patients with CP and 105 periodontally healthy… CONTINUE READING