Tissue plasminogen activator and glial function.

  title={Tissue plasminogen activator and glial function.},
  author={Iordanis Gravanis and Stella E. Tsirka},
  volume={49 2},
Tissue plasminogen activator (tPA) is the only FDA-approved treatment of thrombotic stroke and is a major parenchymal serine protease in the brain. However, it has been implicated in a plethora of brain pathologies, raising concern about its use as a safe therapeutic. tPA is thought to regulate physiological processes that entail tissue remodeling and plasticity, purportedly due to its ability to initiate the degradation of extracellular matrix proteins and possibly other substrates… CONTINUE READING


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