Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4.

@article{Emmetsberger2010TissuePA,
  title={Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4.},
  author={Jaime Emmetsberger and Martine M. Mirrione and Chun Zhou and M{\'o}nica Fern{\'a}ndez-Monreal and Mustafa M. Siddiq and Kyungmin Ji and Stella E. Tsirka},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 19},
  pages={6538-47}
}
Glutamatergic neurons contain free zinc packaged into neurotransmitter-loaded synaptic vesicles. Upon neuronal activation, the vesicular contents are released into the synaptic space, whereby the zinc modulates activity of postsynaptic neurons though interactions with receptors, transporters and exchangers. However, high extracellular concentrations of zinc trigger seizures and are neurotoxic if substantial amounts of zinc reenter the cells via ion channels and accumulate in the cytoplasm… CONTINUE READING
Highly Cited
This paper has 36 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Zinc and tissue plasminogen activator in the mammalian central nervous system

  • M Siddiq
  • PhD thesis,
  • 2003
Highly Influential
6 Excerpts

Data analysis for X-ray fluorescence imaging

  • S Vogt, J Maser, C Jacobsen
  • J Phys IV
  • 2003
Highly Influential
3 Excerpts

location at the plasma membrane

  • YH Kim, JH Park, SH Hong, JY Koh
  • J Biol Chem
  • 1999
Highly Influential
5 Excerpts

The zinc transporter

  • ME Kraenzlin
  • 2008

The zinc transporter SLC 39 A 13 / ZIP 13 is required for connective tissue development ; its involvement in BMP / TGF - beta signaling pathways

  • T Fukada, N Civic, +17 authors ME Kraenzlin
  • J Neurosci Methods
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…