Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

@article{Wang1998TissuePA,
  title={Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice},
  author={Yanming F. Wang and Stella E. Tsirka and Sidney Strickland and Philip E. Stieg and Sulpicio G. Soriano and Stuart Lipton},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={228-231}
}
Intravenous tissue plasminogen activator (tPA) is used to treat acute stroke because of its thrombolytic activity and its ability to restore circulation to the brain1,2. However, this protease also promotes neurodegeneration after intracerebral injection of excitotoxins such as glutamate, and neuronal damage after a cerebral infarct is thought to be mediated by excitotoxins3–8. To investigate the effects of tPA on cerebral viability during ischemia/reperfusion, we occluded the middle cerebral… CONTINUE READING
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