Tissue perfusion and oxygenation with blood substitutes.

  title={Tissue perfusion and oxygenation with blood substitutes.},
  author={O. Habler and K. Messmer},
  journal={Advanced drug delivery reviews},
  volume={40 3},
As an alternative to transfusion of red blood cells, intravenously (iv) administered artificial oxygen (O(2)) carriers are intended to increase the reduced O(2) carrying capacity of blood in the case of acute severe anemia, i.e. hemorrhagic shock or extreme normovolemic hemodilution (ANH). Actually, two groups of artificial O(2) carriers are investigated: ultrapurified, stroma-free hemoglobin solutions (SFH) of human or bovine origin and synthetically produced perfluorocarbons (PFC). SFH may be… CONTINUE READING


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