Tissue oxygenation in low flow states and during hypoxemia.

  title={Tissue oxygenation in low flow states and during hypoxemia.},
  author={Cyril M. Grum},
  journal={Critical care medicine},
  volume={21 2 Suppl},
BACKGROUND AND METHODS Tissue oxygenation during ischemia and hypoxia is critical to cellular viability. Adequate tissue oxygenation reflects a balance between oxygen delivery (DO2) and oxygen demand. At critical levels of DO2, oxygen consumption (VO2) declines due to supply dependency, indicating inadequate tissue oxygenation and impaired cellular metabolism. The mechanism by which DO2 is compromised (hypoxia vs. ischemia) determines the level of delivery at which VO2 becomes supply dependent… CONTINUE READING


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