Tissue microarray constructs to predict a response to chemoradiation in rectal cancer.

@article{Huerta2010TissueMC,
  title={Tissue microarray constructs to predict a response to chemoradiation in rectal cancer.},
  author={S Huerta and John Hrom and Xiaohuan Gao and Debabrata Saha and Thomas Anthony and Henry Reinhart and Payal Kapur},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2010},
  volume={42 10},
  pages={679-84}
}
PURPOSE To identify, using tissue microarray (TMA), an immunohistochemical panel predictive of response to ionizing radiation (IR) in rectal cancer. METHODS TMA constructs were prepared from archived stage II/III rectal tumors and matching adjacent mucosa (n=38) from patients treated with pre-operative chemoradiation. Immunohistochemistry (IHC) was performed for MIB, Cyclin E, p21, p27, p53, survivin, Bcl-2, and BAX. Immunoreactivity along with clinical variables was subjected to univariate… CONTINUE READING

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