Tissue microarray analysis of EGFR and erbB2 copy number changes in ovarian tumors.

@article{Dimova2006TissueMA,
  title={Tissue microarray analysis of EGFR and erbB2 copy number changes in ovarian tumors.},
  author={Ivanka Dimova and Boriana Zaharieva and S Raitcheva and Rumen D. Dimitrov and Nicolai Doganov and Draga Toncheva},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2006},
  volume={16 1},
  pages={
          145-51
        }
}
The objective of this study was to assess the implication of copy number changes of epidermal growth factor receptor (EGFR) and erbB2 genes in the etiology and progression of ovarian tumors. In our study, we used the highly reliable method of fluorescent in situ hybridization, applied on tissue microarray, containing 1006 ovarian tumors from different malignancy, histologic type and grade, and tumor stage, in order to analyze the correlations between gene copy number changes and tumor phenotype… CONTINUE READING

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