Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline.

@article{Wilson2009TissueMC,
  title={Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline.},
  author={Fiona A. Wilson and Joost J. G. C. van den Borne and A. Graham Calder and Niamh O'Kennedy and Grietje Holtrop and William David Rees and Gerald E. Lobley},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 4},
  pages={E702-13}
}
Impaired transfer of methyl groups via the methionine cycle leads to plasma hyperhomocysteinemia. The tissue sources of plasma homocysteine in vivo have not been quantified nor whether hyperhomocysteinemia is due to increased entry or decreased removal. These issues were addressed in female rats offered diets with either adequate or excess methionine (additional methyl groups) with or without folate and choline (impaired methyl group transfer) for 5 wk. Whole body and tissue metabolism was… CONTINUE READING

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