Tissue macrophage identity and self-renewal.

  title={Tissue macrophage identity and self-renewal.},
  author={Rebecca Gentek and Kaaweh Molawi and Michael H Sieweke},
  journal={Immunological reviews},
  volume={262 1},
Macrophages are cellular components of the innate immune system that reside in virtually all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all tissue-resident macrophages derive from the bone marrow through circulating monocyte intermediates has dramatically shifted recently with the observation that macrophages from embryonic progenitors can persist into adulthood and self-maintain by local proliferation. In several tissues, however, monocytes also… CONTINUE READING
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