Tissue macrophage identity and self‐renewal

  title={Tissue macrophage identity and self‐renewal},
  author={Rebecca Gentek and Kaaweh Molawi and Michael H Sieweke},
  journal={Immunological Reviews},
Macrophages are cellular components of the innate immune system that reside in virtually all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all tissue‐resident macrophages derive from the bone marrow through circulating monocyte intermediates has dramatically shifted recently with the observation that macrophages from embryonic progenitors can persist into adulthood and self‐maintain by local proliferation. In several tissues, however, monocytes also… 

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