Tissue levels and biological effects of N-nitrosodimethylamine in mice during chronic low or high dose exposure with or without ethanol.

@article{Anderson1986TissueLA,
  title={Tissue levels and biological effects of N-nitrosodimethylamine in mice during chronic low or high dose exposure with or without ethanol.},
  author={L Meadow Anderson and George W. Harrington and Harry M Pylypiw and Akeo Hagiwara and Peter N. Magee},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1986},
  volume={14 6},
  pages={733-9}
}
In a study of the metabolism, disposition, and hepatotoxicity of the environmental carcinogen N-nitrosodimethylamine (NDMA), as a function of dose in the drinking water and of concomitant administration of ethanol, outbred Swiss mice were given NDMA for 1-4 weeks at levels of 50-0.5 ppm, with or without 10, 20, or 30% ethanol. NDMA, assayed in blood, liver, kidney, lung, and brain by thermal energy analysis after methylene chloride extraction, was detectable (greater than 0.5 ppb) in tissues of… CONTINUE READING

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