Tissue kallikrein KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins.

@article{Dedio2001TissueKK,
  title={Tissue kallikrein KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins.},
  author={J{\"u}rgen Dedio and Gabriele Wiemer and Hartmut Ruetten and Andreas Dendorfer and Bernward A. Sch{\"o}lkens and Werner M{\"u}ller-Esterl and Paulus Wohlfart},
  journal={Biological chemistry},
  year={2001},
  volume={382 10},
  pages={1483-90}
}
Bradykinin released by the endothelium is thought to play an important local role in cardiovascular regulation. However, the molecular identity of endothelial proteases liberating bradykinin from its precursors remained unclear. Using RT-PCR and Southern blotting techniques we detected mRNA for tissue kallikrein (KLK1) in human umbilical vein endothelial cells and in bovine aortic endothelial cells. Protein expression was confirmed by precipitation of KLK1 from lysates of endothelial cells pre… CONTINUE READING
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