Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability.

@article{Espina2009TissueIA,
  title={Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability.},
  author={Virginia Espina and Claudius Mueller and Kirsten H Edmiston and Manuela Sciro and Emanual F. Petricoin and Lance A. Liotta},
  journal={Proteomics. Clinical applications},
  year={2009},
  volume={3 8},
  pages={874-882}
}
Instability of tissue protein biomarkers is a critical issue for molecular profiling. Pre-analytical variables during tissue procurement, such as time delays during which the tissue remains stored at room temperature, can cause significant variability and bias in downstream molecular analysis. Living tissue, ex vivo, goes through a defined stage of reactive changes that begin with oxidative, hypoxic and metabolic stress, and culminate in apoptosis. Depending on the delay time ex vivo, and… CONTINUE READING

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