Tissue inhibitors of metalloproteinases: evolution, structure and function.

  title={Tissue inhibitors of metalloproteinases: evolution, structure and function.},
  author={Keith Brew and Deendayal Dinakarpandian and Hideaki Nagase},
  journal={Biochimica et biophysica acta},
  volume={1477 1-2},
The matrix metalloproteinases (MMPs) play a key role in the normal physiology of connective tissue during development, morphogenesis and wound healing, but their unregulated activity has been implicated in numerous disease processes including arthritis, tumor cell metastasis and atherosclerosis. An important mechanism for the regulation of the activity of MMPs is via binding to a family of homologous proteins referred to as the tissue inhibitors of metalloproteinases (TIMP-1 to TIMP-4). The two… CONTINUE READING
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