Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

@article{Kopitz2007TissueIO,
  title={Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.},
  author={Charlotte C Kopitz and Michael Gerg and Obul Reddy Bandapalli and Dilek Ister and Caroline J. Pennington and Stephanie Hauser and Christin Flechsig and H L Krell and Dalibor Antolovic and Keith Brew and Hideaki Nagase and Manfred Stangl and Claus Werner Hann von Weyhern and Bj{\"o}rn Lucas Dietrich Maria Br{\"u}cher and Karsten Brand and Lisa M. Coussens and Dylan R W Edwards and Achim Kr{\"u}ger},
  journal={Cancer research},
  year={2007},
  volume={67 18},
  pages={8615-23}
}
Balanced expression of proteases and their inhibitors is one prerequisite of tissue homeostasis. Metastatic spread of tumor cells through the organism depends on proteolytic activity and is the death determinant for cancer patients. Paradoxically, increased expression of tissue inhibitor of metalloproteinases-1 (TIMP-1), a natural inhibitor of several… CONTINUE READING