Tissue inhibitor of metalloproteinases (TIMP-1) produced by granulosa and oviduct cells enhances in vitro development of bovine embryo.

Abstract

Embryogenesis-stimulating activity (ESA) was found in serum-free conditioned media (CM) of bovine cumulus/granulosa cells (BGC) and bovine oviductal epithelial cells (BOEC). The CM of BGC (BGC-CM) contained two molecular species of ESA, one with a low molecular weight (M(r) 30,000) and another with a high molecular weight (M(r) 80,000); but only the… (More)

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@article{Satoh1994TissueIO, title={Tissue inhibitor of metalloproteinases (TIMP-1) produced by granulosa and oviduct cells enhances in vitro development of bovine embryo.}, author={T. Satoh and K. Kobayashi and Shinji Yamashita and Mihoko Kikuchi and Yutaka Sendai and Hidehito Hoshi}, journal={Biology of reproduction}, year={1994}, volume={50 4}, pages={835-44} }