Tissue inhibitor of metalloproteinases (TIMP-1) produced by granulosa and oviduct cells enhances in vitro development of bovine embryo.

@article{Satoh1994TissueIO,
  title={Tissue inhibitor of metalloproteinases (TIMP-1) produced by granulosa and oviduct cells enhances in vitro development of bovine embryo.},
  author={Tetsuo Satoh and Kyoko Kobayashi and Shoko Yamashita and Mamoru Kikuchi and Yutaka Sendai and Hiroyoshi Hoshi},
  journal={Biology of reproduction},
  year={1994},
  volume={50 4},
  pages={835-44}
}
Embryogenesis-stimulating activity (ESA) was found in serum-free conditioned media (CM) of bovine cumulus/granulosa cells (BGC) and bovine oviductal epithelial cells (BOEC). The CM of BGC (BGC-CM) contained two molecular species of ESA, one with a low molecular weight (M(r) 30,000) and another with a high molecular weight (M(r) 80,000); but only the… CONTINUE READING