Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance

@inproceedings{Fountoulakis2013TissueIO,
  title={Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance},
  author={Nikitas Fountoulakis and Georgios Labiris and Antonios P. Aristeidou and Andreas Katsanos and Ioannis K. Tentes and Alexandros Kortsaris and Vassilios Kozobolis},
  booktitle={BMC ophthalmology},
  year={2013}
}
BACKGROUND To quantify the levels of tissue inhibitor of metalloproteinase 4 (TIMP4) and its ratios with free metalloproteinases (MMP) in the aqueous humor of patients with primary open angle glaucoma (POAG), pseudoexfoliation syndrome (PXS) and pseudoexfoliative glaucoma (PXG) and to evaluate a possible imbalance between MMPs and TIMPs in these samples. METHODS Free MMP2, MMP3, MMP9, TIMP1, TIMP2, TIMP4 concentrations and active levels of MMP2 and MMP3 were determined with immunoassay ELISA… CONTINUE READING

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The role of TIMPs in regulation of extracellular matrix proteolysis.

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