Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.

@article{Chetty2008TissueIO,
  title={Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.},
  author={C. Sree Ramulu Chetty and S. Lakka and Praveen Bhoopathi and Sateesh Kunigal and Roger W Geiss and J. Sunil Rao},
  journal={Cancer research},
  year={2008},
  volume={68 12},
  pages={4736-45}
}
Matrix metalloproteinase-2 (MMP-2) expression is often up-regulated in advanced cancers and known to play an important role in tumor angiogenesis. We previously showed that adenoviral-mediated delivery of siRNA for MMP-2 (Ad-MMP-2-Si) inhibited lung cancer growth, angiogenesis, and metastasis. In this study, we investigated the signaling mechanisms involved… CONTINUE READING