Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury.

@article{Wallace2002TissueIO,
  title={Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury.},
  author={James A. Wallace and Susan C Alexander and Eduardo Y. Estrada and Curt Hines and Lee Anna Cunningham and Gary A Rosenberg},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2002},
  volume={22 11},
  pages={1303-10}
}
Programmed cell death occurs in ischemia when cell surface death receptors (DRs) are stimulated by death-inducing ligands (DILs). Matrix metalloproteinases are extracellular matrix-degrading enzymes involved in the shedding of DRs and DILs from the cell surface. Tissue inhibitor of metalloproteinase-3 (TIMP-3), which is bound to the extracellular matrix, has been shown to promote apoptosis in cancer cell lines by inhibiting cell surface sheddases. Since apoptosis is an important mechanism of… CONTINUE READING

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