Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.

@article{Menghini2009TissueIO,
  title={Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.},
  author={Rossella Menghini and Stefano Menini and Roberta Amoruso and Loredana Fiorentino and Viviana Casagrande and Valeria Marzano and Federica Tornei and Pierfrancesco Bertucci and Carla Iacobini and Matteo Serino and Ottavia Porzio and Marta Letizia Hribal and Franco Folli and Rama Khokha and Andrea Urbani and Renato Lauro and Giuseppe Pugliese and Massimo Federici},
  journal={Gastroenterology},
  year={2009},
  volume={136 2},
  pages={663-72.e4}
}
BACKGROUND & AIMS Obesity-driven, low-grade inflammation affects systemic metabolic function and can lead to insulin resistance, hepatic steatosis, and atherosclerosis. Decreased expression of tissue inhibitor of metalloproteinase 3 (Timp3) is a catalyst for insulin resistance and inflammation. Timp3 is a natural inhibitor of matrix metalloproteinases, tumor necrosis factor-alpha-converting enzyme (TACE), and vascular endothelial growth factor receptor 2, and therefore could affect signaling… CONTINUE READING

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