Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.

@article{Lee2005TissueIO,
  title={Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.},
  author={Marie Mei Lee and Bong-June Yoon and Keith Osiewicz and Michael Preston and Brian Bundy and Anna M van Heeckeren and Zena Werb and Paul D. Soloway},
  journal={Infection and immunity},
  year={2005},
  volume={73 1},
  pages={661-5}
}
Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections… CONTINUE READING
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