Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.

@article{Kurschat1999TissueIO,
  title={Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.},
  author={Peter Kurschat and Paola Zigrino and Roswitha Nischt and Katja Breitkopf and P Steurer and C. Eberhard Klein and Thomas Krieg and Cornelia Mauch},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 30},
  pages={21056-62}
}
Activation of pro-matrix metalloproteinase (MMP)-2 on the surface of malignant cells by membrane-bound MT1-MMP is believed to play a critical role during tumor progression and metastasis. In this study we present evidence that MT1-MMP plays a key role for the in vitro invasiveness of malignant melanoma. Melanoma cell lines secreted latent MMP-2 when cultured on plastic. However, when cells were grown in floating type I collagen lattices, only high invasive melanoma cells activated proMMP-2… CONTINUE READING

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