Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans

@article{Meissburger2011TissueIO,
  title={Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans},
  author={Bettina Meissburger and Lena Stachorski and Eva Roeder and Gottfried Rudofsky and Christian Wolfrum},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={1468-1479}
}
Extracellular matrix reorganisation is a crucial step of adipocyte differentiation and is controlled by the matrix metalloproteinase–tissue inhibitor of matrix metalloproteinase (TIMP) enzyme system. We therefore sought to define the role of TIMP1 in adipogenesis and to elucidate whether upregulation of TIMP1 in obesity has direct effects on adipocyte formation. TIMP1 protein levels and mRNA were measured in lean and obese mice with a focus on levels in adipose tissue. We also analysed the… CONTINUE READING
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