Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo.

Abstract

We describe here the development and characterization of a conditionally inducible mouse model expressing Lifeact-GFP, a peptide that reports the dynamics of filamentous actin. We have used this model to study platelets, megakaryocytes and melanoblasts and we provide evidence that Lifeact-GFP is a useful reporter in these cell types ex vivo. In the case of… (More)
DOI: 10.1016/j.ejcb.2012.04.002

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