Tissue imaging and serum lipidomic profiling for screening potential biomarkers of thyroid tumors by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry.

@article{Guo2014TissueIA,
  title={Tissue imaging and serum lipidomic profiling for screening potential biomarkers of thyroid tumors by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry.},
  author={Shuai Guo and Ling Qiu and Yanming Wang and Xuzhen Qin and Hui Liu and Manwen He and Yaping Zhang and Zhili Li and Xiaohong Chen},
  journal={Analytical and bioanalytical chemistry},
  year={2014},
  volume={406 18},
  pages={4357-70}
}
Changes in serum lipidome and in tissue lipidome are associated with cancer. In this study, tissue mass spectrometry imaging (MSI) and serum lipid profiling by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS) were performed to investigate significantly changed lipids in both tumor (malignant thyroid cancer (MTC) and benign thyroid tumor (BTT)) tissues and sera. Y-scatterplots of variable importance in the projection (VIP… CONTINUE READING
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