Tissue hypoxia in sleep apnea syndrome assessed by uric acid and adenosine.

  title={Tissue hypoxia in sleep apnea syndrome assessed by uric acid and adenosine.},
  author={Hiroshi Saito and Masaharu Nishimura and Eiji Shibuya and Hironi Makita and Ichizo Tsujino and Kenji Miyamoto and Yoshikazu Kawakami},
  volume={122 5},
STUDY OBJECTIVE Although the overnight increase in urinary uric acid/creatinine ratio (DeltaUA/Cr) is considered by some to be a marker of tissue hypoxia in patients with obstructive sleep apnea-hypopnea syndrome (OSAS), this index is not universally accepted. The purpose of this study was to confirm the validity of DeltaUA/Cr as a marker of tissue hypoxia by measuring the plasma level of adenosine during sleep, and also to test the hypothesis that the heart rate (HR) response to apnea is a… CONTINUE READING

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