Tissue hypoxia activates JNK in the liver during hemorrhagic shock.

@article{McCloskey2004TissueHA,
  title={Tissue hypoxia activates JNK in the liver during hemorrhagic shock.},
  author={Carol A McCloskey and Marina V. Kameneva and Arkady Uryash and David Jim{\'e}nez Gallo and Timothy R Billiar},
  journal={Shock},
  year={2004},
  volume={22 4},
  pages={380-6}
}
The earliest signaling pathways responsible for initiating the systemic response to hemorrhagic shock (HS) remain poorly characterized. We have investigated the involvement of the mitogen-activated protein (MAP) kinase C-JUN N-terminal kinase (JNK) and its activation in the liver as an early response to tissue hypoxia soon after the initiation of hemorrhage… CONTINUE READING