Tissue histopathology, clinical chemistry and behaviour of adult Comt-gene-disrupted mice.

  title={Tissue histopathology, clinical chemistry and behaviour of adult Comt-gene-disrupted mice.},
  author={Kristiina Haasio and Marko Huotari and Erkki Nissinen and Pekka T. M{\"a}nnist{\"o}},
  journal={Journal of applied toxicology : JAT},
  volume={23 4},
Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure. Because there has been some concern about the consequences of a low COMT activity in the development of oestrogen-dependent cancers and because one of the COMT inhibitors, tolcapone, has caused serious liver injuries in Parkinsonian patients, the histopathology and clinical chemistry of Comt-gene-disrupted mice were studied at… CONTINUE READING


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