Tissue growth controlled by geometric boundary conditions: a simple model recapitulating aspects of callus formation and bone healing.

Abstract

The shape of tissues arises from a subtle interplay between biochemical driving forces, leading to cell growth, division and extracellular matrix formation, and the physical constraints of the surrounding environment, giving rise to mechanical signals for the cells. Despite the inherent complexity of such systems, much can still be learnt by treating… (More)
DOI: 10.1098/rsif.2015.0108

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