Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.

@article{Ahmad2013TissueFS,
  title={Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2.},
  author={Shama Ahmad and Aftab Ahmad and Raymond C. Rancourt and Keith B. Neeves and Joan E. Loader and Tara B Hendry-Hofer and Jorge Di Paola and Susan D Reynolds and Carl W White},
  journal={American journal of respiratory cell and molecular biology},
  year={2013},
  volume={48 1},
  pages={
          94-104
        }
}
Tissue factor (TF) initiates the extrinsic coagulation cascade and is a high-affinity receptor for coagulation factor VII. TF also participates in protease-activated receptor (PAR)1 and PAR2 activation. Human epithelial basal cells were previously purified on the basis of TF expression. The purpose of this study was to determine if tracheobronchial epithelial basal cell-associated TF drives coagulation and/or activates PARs to promote basal cell functions. We used human tracheobronchial tissues… CONTINUE READING
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Fibrin formation by wounded bronchial epithelial cell layers in vitro is essential for normal epithelial repair and independent of plasma proteins.

  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2007
VIEW 4 EXCERPTS
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