Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration.

@article{Gori1999TissueFR,
  title={Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration.},
  author={Anna Maria Gori and Guglielmina Pepe and Monica Attanasio and Michela Falciani and Rosanna Abbate and Domenico Prisco and Sandra Fedi and Betti Giusti and Tamara Brunelli and Paolo Comeglio and Gian Franco Gensini and Gian Gastone Neri Serneri},
  journal={Thrombosis and haemostasis},
  year={1999},
  volume={81 4},
  pages={589-93}
}
Elevated plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) and large amounts of monocyte procoagulant activity (PCA) have been documented in unstable angina (UA) patients. In in vitro experiments heparin is able to blunt monocyte TF production by inhibiting TF and cytokine gene expression by stimulated cells and after in vivo administration it reduces adverse ischemic outcomes in UA patients. TF and TFPI plasma levels and monocyte PCA have been investigated in 28… CONTINUE READING