Tissue factor production by cultured rat mesangial cells. Stimulation by TNF alpha and lipopolysaccharide.

Abstract

Fibrin formation plays an important role in glomerular injury. We therefore examined the procoagulant signal produced by cultured rat mesangial cells. Actively growing mesangial cells produced procoagulant activity (PCA) that was present in intact cells (surface-associated), was inhibitable by cyclohexamide and which, by clotting assay, had the… (More)

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