Tissue factor pathway inhibitor: proposed heparin recognition region.

  title={Tissue factor pathway inhibitor: proposed heparin recognition region.},
  author={Job Harenberg and Reinhard Malsch and Dieter L. Heene},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  volume={6 Suppl 1},
After intravenous and subcutaneous injection, heparins and low-molecular-weight heparins release tissue factor pathway inhibitor (TFPI) into the blood stream. Protamine immediately reverses the plasma levels of TFPI to pretreatment values. A low-molecular-weight dermatan sulphate releases only very small amounts of TFPI after intravenous injection without a clear dose-dependent effect. Together with other data from literature, it seems likely that TFPI is rather specifically released by acidic… CONTINUE READING