Tissue factor on cells.

  title={Tissue factor on cells.},
  author={L Vijaya Mohan Rao and Usha R Pendurthi},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  volume={9 Suppl 1},
Tissue factor (TF), a cell surface glycoprotein, serves as the cellular receptor for either activated or non-activated factor VII [FVII(a)] and it is the formation of TF-FVII(a) complexes on cell surfaces which triggers the coagulation cascade in vivo. TF procoagulant functional expression on cell surfaces can be regulated by at least three distinct major mechanisms: (1) transcriptional regulation of TF gene expression; (2) cell membrane alterations in cells expressing TF; and (3… CONTINUE READING
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