Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice.

@article{Schoenmakers2004TissueFH,
  title={Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice.},
  author={Saskia Schoenmakers and Henri H Versteeg and Angelique P A Groot and Pieter H. Reitsma and C. Arnold Spek},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2004},
  volume={2 12},
  pages={
          2185-93
        }
}
Intervention studies blocking tissue factor (TF) driven coagulation show beneficial effects on survival in endotoxemia models by reducing cytokine production. It is unknown, however, if moderately reduced TF levels influence endotoxemia. The objective was to investigate whether TF haploinsufficiency reduces endotoxin-induced cytokine production in murine cells or in mice. We analyzed the intrinsic capacity of heterozygous TF deficient (TF+/-) leukocytes to produce cytokines. In addition, we… CONTINUE READING
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