Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease.

@article{Kambas2014TissueFE,
  title={Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease.},
  author={Konstantinos Kambas and Akrivi Chrysanthopoulou and Dimitrios Vassilopoulos and Eirini Apostolidou and Panagiotis Skendros and Andreas Girod and Stella Arelaki and Marios E Froudarakis and Lydia L Nakopoulou and Alexandra N Giatromanolaki and Prodromos I Sidiropoulos and Maria Koffa and Dimitrios T. Boumpas and Konstantinos Ritis and Ioannis Mitroulis},
  journal={Annals of the rheumatic diseases},
  year={2014},
  volume={73 10},
  pages={1854-63}
}
OBJECTIVES Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events has been reported in AAV. Because of the critical role of neutrophils in inflammation associated thrombosis, we asked whether neutrophil tissue factor (TF) may be implicated in the thrombotic diathesis in AAV. METHODS Neutrophils from four patients and sera from 17 patients with ANCA associated vasculitis with… CONTINUE READING
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