Tissue factor expression in human leukocytes and tumor cells.

  title={Tissue factor expression in human leukocytes and tumor cells.},
  author={Frederick R. Rickles and Gregory A Hair and Richard A. Zeff and Eun-Jin Lee and R. D. Bona},
  journal={Thrombosis and haemostasis},
  volume={74 1},
Tissue factor (TF) exists in a cryptic form [i.e. without procoagulant activity (PCA)] in peripheral blood monocytes and quiescent tissue macrophages but is expressed constitutively in most human tumor cells. Induction and cell surface expression of TF in these cells in vivo is associated with activation of intravascular and extravascular coagulation in patients with a variety of inflammatory or malignant diseases. The regulation of TF synthesis in cells is complex and new information from… CONTINUE READING

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