Tissue factor-enriched vesicles are taken up by platelets and induce platelet aggregation in the presence of factor VIIa.

@article{LpezVlchez2007TissueFV,
  title={Tissue factor-enriched vesicles are taken up by platelets and induce platelet aggregation in the presence of factor VIIa.},
  author={Irene L{\'o}pez-V{\'i}lchez and Gin{\'e}s Escolar and Maribel D{\'i}az-Ricart and Berta Fust{\'e} and Ana Mar{\'i}a Gal{\'a}n and J. Gaines White},
  journal={Thrombosis and haemostasis},
  year={2007},
  volume={97 2},
  pages={202-11}
}
We investigated the interactions of vesicles containing human tissue factor (TF) with platelets and evaluated responses induced by rFVIIa using standard aggregometry, ultrastructural and flow-cytometry techniques. Washed platelets were exposed to a preparation of placental human TF (pTF) or to a relipidated formulation of recombinant human TF (rTF). Under stirring conditions, pTF induced reversible aggregation with platelets returning to their resting state after 5 minutes. This reversible… CONTINUE READING