Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activation.

@article{Dvila2008TissueFM,
  title={Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activation.},
  author={M{\'o}nica D{\'a}vila and Ali Amirkhosravi and Enriqueta Coll and Hina Desai and Lourdes Robles and Jimmie E Col{\'o}n and Cheryl Baker and John L. Francis},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 9},
  pages={1517-24}
}
BACKGROUND Tissue factor (TF)-bearing microparticles (MP) from different origins are thought to be involved in the pathogenesis of cancer-associated thrombosis. However, the role of circulating tumor cell-derived TF is not well understood. METHODS TF antigen and activity were measured in MP generated in vitro from human TF-expressing cancer cells by ELISA and clotting or thrombin generation assays, respectively. TF antigen and activity were also measured in vivo in cell-free plasmas from mice… CONTINUE READING