Tissue factor activity and function in blood coagulation.

@article{Butenas2008TissueFA,
  title={Tissue factor activity and function in blood coagulation.},
  author={Saulius Butenas and Thomas Orfeo and Kenneth G. Mann},
  journal={Thrombosis research},
  year={2008},
  volume={122 Suppl 1},
  pages={
          S42-6
        }
}
Tissue factor (TF) is the major physiological initiator of blood coagulation. It exists as an integral membrane protein that upon injury to the blood vessel becomes exposed to the blood stream and initiates a series of enzymatic reactions that cause blood to clot. TF is also found within circulating blood cells, requiring specific signaling events to promote its expression. In this review we will discuss current controversies concerning the structure-activity relationships of TF and… CONTINUE READING
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