Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury.

@article{Redecha2007TissueFA,
  title={Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury.},
  author={Patricia Redecha and Rachel E. Tilley and Michael Tencati and Jane E. Salmon and Daniel Kirchhofer and Nigel Mackman and Guillermina Girardi},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={2423-31}
}
Fetal loss in patients with antiphospholipid (aPL) antibodies has been ascribed to thrombosis of placental vessels. However, we have shown that inflammation, specifically activation of complement with generation of the anaphylotoxin C5a, is an essential trigger of fetal injury. In this study, we analyzed the role of the procoagulant molecule tissue factor (TF) in a mouse model of aPL antibody-induced pregnancy loss. We found that either blockade of TF with a monoclonal antibody in wild-type… CONTINUE READING

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