Tissue factor/factor VIIa complex: role of the membrane surface.

  title={Tissue factor/factor VIIa complex: role of the membrane surface.},
  author={James H Morrissey and Emad Tajkhorshid and Stephen G Sligar and Chad M Rienstra},
  journal={Thrombosis research},
  volume={129 Suppl 2},
Blood clotting is triggered when the plasma serine protease factor VIIa binds to the cell-surface protein, tissue factor (TF); the resulting TF:FVIIa complex activates factors IX (FIX) and X (FX) by limited proteolysis. FVIIa, FIX and FX all bind reversibly to membranes via their gamma-carboxyglutamate-rich (GLA) domains, while TF is an integral membrane protein. Removing these proteases from the membrane surface is known to render them thousands of times less active, although the mechanisms by… CONTINUE READING