Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

  title={Tissue expression and subcellular localization of the pro-survival molecule Bcl-w},
  author={Lorraine A O'reilly and Cristin G. Print and George Hausmann and K Moriishi and Suzanne Cory and David C S Huang and Andreas Strasser},
  journal={Cell Death and Differentiation},
Anti-apoptotic members of the Bcl-2 family, such as Bcl-w, maintain cell viability by preventing the activation of the cell death effectors, the caspases. Gene targeting experiments in mice have demonstrated that Bcl-w is required for spermatogenesis and for survival of damaged epithelial cells in the gut. Bcl-w is, however, dispensable for physiological cell death in other tissues. Here we report on the analysis of Bcl-w protein expression using a panel of novel monoclonal antibodies. Bcl-w is… CONTINUE READING


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and its product localizes to mitochondria

G Hausmann, LA O'Reilly, +4 authors Huang DCS

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