Tissue expression and plasma levels of adrenomedullin in renal cancer patients.

Abstract

The peptide AM (adrenomedullin) is stimulated by hypoxia through HIF-1 (hypoxia-inducible factor-1). The majority of human CC-RCCs (clear cell renal cell carcinomas) display mutations in the tumour suppressor protein von Hippel-Lindau, which leads to constitutively elevated HIF-1. We hypothesized that AM is increased in CC-RCC tumours and that AM is a… (More)

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Cite this paper

@article{Michelsen2006TissueEA, title={Tissue expression and plasma levels of adrenomedullin in renal cancer patients.}, author={Jens Michelsen and Helle Charlotte Thiesson and S Leal Walter and Peter David Ottosen and Ole Sk\ott and Boye Lagerbon Jensen}, journal={Clinical science}, year={2006}, volume={111 1}, pages={61-70} }